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KMID : 0366220070420020162
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Korean Journal of Hematology
2007 Volume.42 No. 2 p.162 ~ p.166
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A Case of Henoch-Schonlein Purpura Associated with Diffuse Large B Cell Lymphoma
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Kim Il-Du
Lee Seung-Geun
Lee Hae-Jung
Jo Woo-Sung
Choi Young-Jin
Shin Ho-Jin
Chung Joo-Seop
Cho Goon-Jae
Lee Eun-Yup
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Abstract
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A 69-year-old female was referred to our institution due to abdominal pain and palpable purpura on both buttocks and legs. A skin biopsy of her purpura revealed granulocyte infiltration and leucocytoclasia around the arterioles and venuoles at the dermis, as well as an elevated serum immunoglobulin A level, hematuria and proteinuria. Therefore she was diagnosed with Henoch-Schonlein purpura. She had been diagnosed with diffuse large B cell lymphoma after a biopsy of her left inguinal lymph node 12 years ago and received 6 cycles of CHOP (cyclophosphamide, doxorubicin, vincristine and prednisone) chemotherapy, which was followed by a complete remission. Abdominal and chest CT revealed multiple lymph node enlargement and bowel wall thickening at the ileocecal area, and lesions were observed in a whole body PET CT scan. Recurrence of the diffuse large B cell lymphoma was confirmed by a biopsy of the ileocecal area via colonoscopy. The purpura was improved after oral prednisolone therapy and etoposide, oxaliplatin and ifosfamide salvage combination chemotherapy was used to treat the lymphoma. (Korean J Hematol 2007;42:162-166.)
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KEYWORD
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Henoch-Schonlein purpura, Diffuse large B cell lymphoma, Malignancy, Vasculitis
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